ECD

Across TCGA patient cohorts, ECD mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ECD-associated genes across cancer lineages are ATM, A-Raf_pS299, and Acetyl-a-Tubulin-Lys40. Each is linked with ECD in more than 1 cancer types. Because this analysis shows association rather than direction, both ECD-to-partner and partner-to-ECD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ECD-low versus ECD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ECD→partner) and Y-score (partner→ECD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.676	-2.986	<.001	.035	3	2
UCEC	A-Raf_pS299 →	-0.170	-2.115	.001	.019	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.512	+2.179	.021	.034	3	1
UCEC	INPP4B →	-0.365	-2.321	.009	.033	3	1
UCEC	MEK1 →	+0.438	+2.459	.006	.019	3	1
UCEC	MSH2 →	-0.370	-3.433	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

ATM by ECD expression — UCEC

Explore this box plot interactively →