EBF1

Across TCGA patient cohorts, EBF1 mutation is significantly associated with the RNA expression of many other genes, with 3,635 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EBF1-associated genes across cancer lineages are LDHAP1, SKA1, and TEDC2. Each is linked with EBF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both EBF1-to-partner and partner-to-EBF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LDHAP1 grouped by EBF1-low versus EBF1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EBF1→partner) and Y-score (partner→EBF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LDHAP1 →	+0.079	+3.974	.001	.002	3	3
UCEC	SKA1 →	+0.611	+3.021	<.001	<.001	3	3
UCEC	TEDC2 →	+0.507	+2.415	<.001	.003	3	3
UCEC	PATL1 →	+0.369	+1.809	.004	.003	3	3
UCEC	TIMM21 →	+0.419	+3.087	<.001	<.001	3	3
UCEC	KTN1-AS1 →	+0.336	+2.632	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,635 associations by consensus.

LDHAP1 by EBF1 expression — BRCA

Explore this box plot interactively →