EAPP

Across TCGA pan-cancer cohorts, EAPP mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated EAPP data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher EAPP mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated EAPP expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

PDAC, CCRCC, and OV are the cancer types where EAPP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.265	0.478	<.001	91	view →
CCRCC	DFS	Median	All	0.862	0.624	.001	12	view →
OV	DFS	Tertile	All	0.545	1.000	.020	8	view →
LSCC	OS	Median	II,III,IV	0.885	0.599	.012	4	view →
LUAD	DFS	Quartile	II,III,IV	1.000	0.288	.031	4	view →
UCEC	DFS	Quartile	All	0.815	1.000	.007	4	view →
HNSC	DFS	Median	II,III,IV	0.985	0.907	.043	2	view →
GBM	DFS	Quartile	All	0.501	0.289	.035	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

EAPP–PDAC (OS)

Open the PDAC breakdown →