EAPP

Across TCGA cell cohorts, EAPP mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EAPP-associated genes across cancer lineages are DAZ4, RBMY1B, and RBMY1D. Each is linked with EAPP in more than 1 cancer types. Because this analysis shows association rather than direction, both EAPP-to-partner and partner-to-EAPP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DAZ4 grouped by EAPP-low versus EAPP-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EAPP→partner) and Y-score (partner→EAPP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DAZ4 →	+0.326	+4.977	<.001	.007	3	1
LARGE_INTESTINE	RBMY1B →	+0.006	+5.415	<.001	.004	3	1
LARGE_INTESTINE	RBMY1D →	+0.006	+5.415	<.001	.004	3	1
SKIN	CRYGD →	+0.530	+4.415	<.001	.007	3	1
SKIN	SLC7A10 →	+0.276	+4.095	<.001	.009	3	1
SKIN	DYTN →	+0.107	+5.217	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

DAZ4 by EAPP expression — LARGE_INTESTINE

Explore this box plot interactively →