EAF2

Across TCGA patient cohorts, EAF2 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EAF2-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and FoxM1. Each is linked with EAF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EAF2-to-partner and partner-to-EAF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by EAF2-low versus EAF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EAF2→partner) and Y-score (partner→EAF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.307	-3.807	.006	<.001	3	1
UCEC	A-Raf_pS299 →	-0.126	-3.169	.019	.019	3	1
UCEC	FoxM1 →	+0.254	+2.000	.029	.032	3	1
UCEC	GATA6 →	-0.143	-2.985	.039	.034	3	1
UCEC	JNK_pT183_Y185 →	-0.196	-2.999	.009	.035	3	1
UCEC	Myosin-IIa_pS1943 →	+0.308	+3.820	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

EGFR_pY1068 by EAF2 expression — UCEC

Explore this box plot interactively →