EAF2

Across TCGA cell cohorts, EAF2 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible EAF2-associated genes across cancer lineages are LYZL1, ODF1, and REC114. Each is linked with EAF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EAF2-to-partner and partner-to-EAF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LYZL1 grouped by EAF2-low versus EAF2-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EAF2→partner) and Y-score (partner→EAF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	LYZL1 →	+0.042	+3.405	<.001	.005	3	1
OVARY	ODF1 →	+0.010	+3.807	<.001	.009	3	1
OVARY	REC114 →	+0.028	+3.095	.003	.009	3	1
LUNG_SCLC	DEFB123 →	+0.077	+4.643	<.001	.004	3	1
LUNG_NSCLC_LUAD	OR56A5 →	+0.111	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	IQCF3 →	+0.045	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

LYZL1 by EAF2 expression — OVARY

Explore this box plot interactively →