E2F7

Across TCGA patient cohorts, E2F7 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible E2F7-associated genes across cancer lineages are VHL, Caspase-7-cleavedD198, and 14-3-3_epsilon. Each is linked with E2F7 in more than 2 cancer types. Because this analysis shows association rather than direction, both E2F7-to-partner and partner-to-E2F7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by E2F7-low versus E2F7-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (E2F7→partner) and Y-score (partner→E2F7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	VHL →	-0.951	-3.169	.038	.019	3	3
UCEC	Caspase-7-cleavedD198 →	+0.564	+1.434	.002	.027	3	3
LUAD	14-3-3_epsilon →	+0.117	+3.169	.033	.019	3	2
LUAD	TFRC →	+0.634	+3.169	.020	.019	3	2
COAD	IGFBP2 →	-0.839	-3.000	.014	.035	3	2
COAD	Chk1_pS345 →	+0.113	+3.012	.039	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

VHL by E2F7 expression — LUAD

Explore this box plot interactively →