E2F7

Across TCGA cell cohorts, E2F7 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,299 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible E2F7-associated GO terms across cancer lineages are Sister chromatid segregation, Chromosome segregation, and Centrosome cycle. Each is linked with E2F7 in more than 18 cancer types. Because this analysis shows association rather than direction, both E2F7-to-partner and partner-to-E2F7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Sister chromatid segregation grouped by E2F7-low versus E2F7-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (E2F7→partner) and Y-score (partner→E2F7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Sister chromatid segregation →	+0.106	+1.308	<.001	<.001	3	19
BONE	Chromosome segregation →	+0.113	+1.317	.003	.003	3	19
LUNG_NSCLC_LUSC	Centrosome cycle →	+0.106	+1.442	.001	.003	2	19
BONE	Nuclear chromosome segregation →	+0.141	+1.596	.005	.001	3	18
BONE	Negative regulation of cell cycle process →	+0.088	+1.691	.004	.002	3	18
BONE	Mitotic nuclear division →	+0.101	+1.301	.007	.005	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,299 associations by consensus.

Sister chromatid segregation by E2F7 expression — BREAST

Explore this box plot interactively →