E2F7

Across TCGA cell cohorts, E2F7 mutation is significantly associated with the RNA expression of many other genes, with 408 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible E2F7-associated genes across cancer lineages are OR10AG1, CBY1, and VAPA. Each is linked with E2F7 in more than 1 cancer types. Because this analysis shows association rather than direction, both E2F7-to-partner and partner-to-E2F7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10AG1 grouped by E2F7-low versus E2F7-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (E2F7→partner) and Y-score (partner→E2F7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR10AG1 →	+0.013	+5.169	<.001	.005	3	1
LARGE_INTESTINE	CBY1 →	+0.792	+3.588	<.001	<.001	3	1
LARGE_INTESTINE	VAPA →	+0.535	+3.169	.003	.009	3	1
LARGE_INTESTINE	METTL4 →	+0.615	+3.067	.001	.009	3	1
LARGE_INTESTINE	FZD3 →	+0.881	+3.502	<.001	.001	3	1
LARGE_INTESTINE	IL7 →	+0.819	+3.588	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 408 associations by consensus.

OR10AG1 by E2F7 expression — BREAST

Explore this box plot interactively →