E2F3

Across TCGA patient cohorts, E2F3 mutation is significantly associated with the RNA expression of many other genes, with 4,038 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible E2F3-associated genes across cancer lineages are SLC25A30, AK6, and CCNJP1. Each is linked with E2F3 in more than 2 cancer types. Because this analysis shows association rather than direction, both E2F3-to-partner and partner-to-E2F3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC25A30 grouped by E2F3-low versus E2F3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (E2F3→partner) and Y-score (partner→E2F3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLC25A30 →	+0.427	+2.043	<.001	.001	3	3
UCEC	AK6 →	+0.397	+2.354	<.001	<.001	3	3
CESC	CCNJP1 →	+0.024	+3.932	<.001	.002	3	2
COAD	RN7SL478P →	+0.294	+5.145	.001	<.001	3	2
UCEC	EI24 →	+0.424	+1.784	<.001	<.001	3	2
UCEC	TIRAP →	+0.433	+1.617	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,038 associations by consensus.

SLC25A30 by E2F3 expression — UCEC

Explore this box plot interactively →