E2F3

Across TCGA patient cohorts, E2F3 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible E2F3-associated genes across cancer lineages are ATM, PDCD4, and Caspase-7-cleavedD198. Each is linked with E2F3 in more than 2 cancer types. Because this analysis shows association rather than direction, both E2F3-to-partner and partner-to-E2F3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by E2F3-low versus E2F3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (E2F3→partner) and Y-score (partner→E2F3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.497	-2.485	<.001	<.001	3	3
UCEC	PDCD4 →	-0.448	-1.643	.002	.003	3	2
UCEC	Caspase-7-cleavedD198 →	+0.525	+1.522	.004	.017	3	2
UCEC	CDK1 →	+0.105	+1.440	.025	.022	3	2
UCEC	eEF2 →	+0.281	+2.000	.011	.009	3	1
UCEC	EGFR_pY1068 →	-0.285	-2.857	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

ATM by E2F3 expression — UCEC

Explore this box plot interactively →