E2F3

Across TCGA cell cohorts, E2F3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,429 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible E2F3-associated GO terms across cancer lineages are Cell cycle G1/S phase transition, Negative regulation of RNA export from nucleus, and DNA-templated DNA replication maintenance of fidelity. Each is linked with E2F3 in more than 18 cancer types. Because this analysis shows association rather than direction, both E2F3-to-partner and partner-to-E2F3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cell cycle G1/S phase transition grouped by E2F3-low versus E2F3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (E2F3→partner) and Y-score (partner→E2F3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Cell cycle G1/S phase transition →	+0.090	+0.792	.001	.005	3	19
SKIN	Negative regulation of RNA export from nucleus →	+0.138	+0.881	<.001	<.001	3	19
LUNG_SCLC	DNA-templated DNA replication maintenance of fidelity →	+0.108	+0.899	<.001	.001	3	18
UPPER_AERODIGESTIVE_TRACT	Nuclear pore complex assembly →	+0.173	+0.770	<.001	<.001	3	18
BONE	G1/S transition of mitotic cell cycle →	+0.083	+0.762	.003	.008	3	18
BONE	DNA-templated DNA replication →	+0.184	+1.036	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,429 associations by consensus.

Cell cycle G1/S phase transition by E2F3 expression — BONE

Explore this box plot interactively →