E2F3

Across TCGA cell cohorts, E2F3 mutation is significantly associated with the mutation status of many other genes, with 3,255 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible E2F3-associated genes across cancer lineages are PDCD11, TRPM6, and PPP1R10. Each is linked with E2F3 in more than 4 cancer types. Because this analysis shows association rather than direction, both E2F3-to-partner and partner-to-E2F3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD11 grouped by E2F3-low versus E2F3-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (E2F3→partner) and Y-score (partner→E2F3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PDCD11 →	+4.584	+4.584	.007	.007	1	5
LUNG_NSCLC_LUAD	TRPM6 →	+2.540	+4.222	.003	.003	1	4
LUNG_NSCLC_LUAD	PPP1R10 →	+5.000	+4.187	.008	.008	1	4
LARGE_INTESTINE	MYO3B →	+2.422	+4.050	.004	.004	1	4
SKIN	CENPF →	+2.977	+4.392	.005	.005	1	4
BLOOD_Lymphoma	SMCR8 →	+4.584	+4.584	.007	.007	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,255 associations by consensus.

PDCD11 by E2F3 expression — BLOOD_Lymphoma

Explore this box plot interactively →