E2F1

Across TCGA patient cohorts, E2F1 protein abundance is significantly associated with the RNA expression of many other genes, with 1,536 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible E2F1-associated genes across cancer lineages are VAT1, DUSP3, and NNT. Each is linked with E2F1 in more than 1 cancer types. Because this analysis shows association rather than direction, both E2F1-to-partner and partner-to-E2F1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, E2F1 versus VAT1 in BRCA, with a Pearson correlation of 0.50.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (E2F1→partner) and Y-score (partner→E2F1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	VAT1 →	+0.714	+0.754	.005	.009	3	1
BRCA	DUSP3 →	+0.593	+0.607	<.001	.009	3	1
BRCA	NNT →	+0.972	+0.604	.001	.008	3	1
BRCA	PGF →	+0.620	+0.643	.009	.004	3	1
BRCA	KLHDC10 →	+0.825	+1.035	.004	.009	3	1
BRCA	NOL11 →	+0.686	+0.622	.005	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,536 associations by consensus.

E2F1 vs VAT1 — BRCA

Explore this scatter interactively →