E2F1

Across TCGA cell cohorts, E2F1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,536 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible E2F1-associated GO terms across cancer lineages are Mitotic DNA replication, Positive regulation of cytokinesis, and Cell cycle DNA replication. Each is linked with E2F1 in more than 17 cancer types. Because this analysis shows association rather than direction, both E2F1-to-partner and partner-to-E2F1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitotic DNA replication grouped by E2F1-low versus E2F1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (E2F1→partner) and Y-score (partner→E2F1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Mitotic DNA replication →	+0.210	+1.513	<.001	<.001	3	18
BONE	Positive regulation of cytokinesis →	+0.138	+1.454	.006	.008	3	18
OESOPHAGUS	Cell cycle DNA replication →	+0.179	+1.388	.003	.003	3	18
BONE	Regulation of DNA-templated DNA replication →	+0.154	+1.927	.001	<.001	3	18
OESOPHAGUS	Chromosome condensation →	+0.189	+1.213	<.001	.001	3	18
UPPER_AERODIGESTIVE_TRACT	DNA strand elongation →	+0.193	+1.595	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,536 associations by consensus.

Mitotic DNA replication by E2F1 expression — BONE

Explore this box plot interactively →