DYSF

Across TCGA cell cohorts, DYSF mutation is significantly associated with the RNA expression of many other genes, with 1,073 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DYSF-associated genes across cancer lineages are SARS1, MUTYH, and NOB1. Each is linked with DYSF in more than 2 cancer types. Because this analysis shows association rather than direction, both DYSF-to-partner and partner-to-DYSF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SARS1 grouped by DYSF-low versus DYSF-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYSF→partner) and Y-score (partner→DYSF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SARS1 →	+0.728	+2.392	.002	.006	3	3
LARGE_INTESTINE	MUTYH →	+0.657	+1.949	<.001	.002	3	3
OVARY	NOB1 →	+0.579	+2.459	.008	.009	3	3
OVARY	IGFBP7 →	-3.833	-2.459	<.001	.009	3	3
BLOOD_Leukemia	LY75 →	-1.349	-1.877	.001	.009	3	3
LARGE_INTESTINE	RCHY1 →	+0.675	+2.182	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,073 associations by consensus.

SARS1 by DYSF expression — STOMACH

Explore this box plot interactively →