DYRK3-AS1

Across TCGA pan-cancer cohorts, DYRK3-AS1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of DYRK3-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where DYRK3-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DYRK3-AS1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, THCA, and LIHC are the cancer types where DYRK3-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DYRK3-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.571	<.001	11	view →
THCA	Male	III,IV	−0.827	<.001	10	view →
LIHC	All	II,III,IV	+0.344	<.001	8	view →
LUSC	Female	All	+0.693	<.001	6	view →
BRCA	All	II,III,IV	+0.486	<.001	6	view →
KIRP	All	II,III,IV	+0.383	.014	6	view →
STAD	Male	IV	+1.015	.001	5	view →
BLCA	All	All	+0.382	.009	5	view →
UCEC	All	All	+0.822	<.001	4	view →
LUAD	All	All	+0.324	<.001	4	view →
COAD	All	All	+0.280	.001	4	view →
KIRC	All	All	+0.126	.006	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

DYRK3-AS1–HNSC

Open the HNSC breakdown →