DYRK2

Across TCGA patient cohorts, DYRK2 mutation is significantly associated with the RNA expression of many other genes, with 4,088 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DYRK2-associated genes across cancer lineages are C12orf43, FUT10, and ERO1B. Each is linked with DYRK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both DYRK2-to-partner and partner-to-DYRK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C12orf43 grouped by DYRK2-low versus DYRK2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYRK2→partner) and Y-score (partner→DYRK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	C12orf43 →	+0.301	+3.342	.001	.005	3	3
UCEC	FUT10 →	+0.329	+1.447	.001	.005	3	3
UCEC	ERO1B →	+0.548	+1.871	.001	.001	3	3
UCEC	FH →	+0.282	+1.609	.005	.002	3	3
UCEC	PHF5A →	+0.512	+2.285	<.001	<.001	3	3
COAD	RNU1-35P →	+0.220	+2.628	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,088 associations by consensus.

C12orf43 by DYRK2 expression — COAD

Explore this box plot interactively →