DYRK2

Across TCGA patient cohorts, DYRK2 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DYRK2-associated genes across cancer lineages are Caspase-7-cleavedD198, ATM, and MEK1. Each is linked with DYRK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both DYRK2-to-partner and partner-to-DYRK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by DYRK2-low versus DYRK2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYRK2→partner) and Y-score (partner→DYRK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.355	+2.708	<.001	.003	3	3
UCEC	ATM →	-0.480	-1.807	<.001	<.001	3	3
UCEC	MEK1 →	+0.291	+1.874	.007	.002	3	2
COAD	Claudin-7 →	+0.644	+2.008	.016	.018	3	2
UCEC	Notch1 →	+0.118	+2.515	.004	<.001	3	2
UCEC	PKC-delta_pS664 →	-0.095	-1.678	.008	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

Caspase-7-cleavedD198 by DYRK2 expression — COAD

Explore this box plot interactively →