DYRK2

Across TCGA cell cohorts, DYRK2 mutation is significantly associated with the RNA expression of many other genes, with 286 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DYRK2-associated genes across cancer lineages are GFRA4, CBY1, and L3MBTL2. Each is linked with DYRK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DYRK2-to-partner and partner-to-DYRK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GFRA4 grouped by DYRK2-low versus DYRK2-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYRK2→partner) and Y-score (partner→DYRK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	GFRA4 →	+0.016	+5.614	<.001	.002	3	1
LARGE_INTESTINE	CBY1 →	+0.594	+3.451	.002	.002	3	1
LARGE_INTESTINE	L3MBTL2 →	+0.625	+3.364	.001	.002	3	1
LARGE_INTESTINE	TRMU →	+0.703	+3.364	<.001	.002	3	1
LARGE_INTESTINE	DDHD1 →	+0.823	+3.364	<.001	.002	3	1
LARGE_INTESTINE	CD40 →	+1.685	+3.354	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 286 associations by consensus.

GFRA4 by DYRK2 expression — PANCREAS

Explore this box plot interactively →