DYRK1A

Across TCGA pan-cancer cohorts, DYRK1A mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated DYRK1A data layer compared with 27 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DYRK1A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DYRK1A expression acts as an unfavorable survival marker, although some lineages such as PDAC and COAD show a favorable association.

HNSC, UCEC, and PDAC are the cancer types where DYRK1A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.671	0.895	.006	12	view →
UCEC	OS	Quartile	III,IV	0.355	1.000	.040	8	view →
PDAC	DFS	Tertile	IV	0.752	0.205	.024	7	view →
COAD	DFS	Median	III,IV	1.000	0.869	.030	6	view →
LUAD	OS	Median	III,IV	0.663	1.000	.007	6	view →
CCRCC	OS	Median	II,III,IV	0.885	0.738	.018	3	view →
LSCC	DFS	Median	III,IV	0.413	0.839	.007	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

DYRK1A–HNSC (DFS)

Open the HNSC breakdown →