DYRK1A

Across TCGA patient cohorts, DYRK1A protein abundance is significantly associated with the RNA expression of many other genes, with 6,961 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DYRK1A-associated genes across cancer lineages are SETD4, PRDM15, and VPS26C. Each is linked with DYRK1A in more than 3 cancer types. Because this analysis shows association rather than direction, both DYRK1A-to-partner and partner-to-DYRK1A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DYRK1A versus SETD4 in OV, with a Pearson correlation of 0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYRK1A→partner) and Y-score (partner→DYRK1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SETD4 →	+0.370	+0.211	<.001	<.001	3	4
HNSC	PRDM15 →	+0.529	+0.206	.001	<.001	3	4
LSCC	VPS26C →	+0.337	+0.259	<.001	<.001	3	4
HNSC	HLCS →	+0.693	+0.164	<.001	<.001	3	4
HNSC	PCNT →	+0.606	+0.170	<.001	<.001	3	4
HNSC	DIP2A →	+0.396	+0.152	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,961 associations by consensus.

DYRK1A vs SETD4 — OV

Explore this scatter interactively →