DYRK1A

Across TCGA patient cohorts, DYRK1A protein abundance is significantly associated with the protein abundance of many other proteins, with 13,167 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DYRK1A-associated proteins across cancer lineages are SCAF4, USP16, and SON. Each is linked with DYRK1A in more than 5 cancer types. Because this analysis shows association rather than direction, both DYRK1A-to-partner and partner-to-DYRK1A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DYRK1A versus SCAF4 in BRCA, with a Pearson correlation of 0.46.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DYRK1A→partner) and Y-score (partner→DYRK1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SCAF4 →	+0.250	+0.203	<.001	<.001	3	5
OV	USP16 →	+0.215	+0.246	<.001	<.001	3	5
BRCA	SON →	+0.208	+0.239	<.001	<.001	3	4
CCRCC	UNK →	+0.259	+0.143	<.001	.001	3	4
BRCA	FAM117B_S345 →	+0.719	+0.302	<.001	<.001	3	4
GBM	GATAD2B →	+0.312	+0.175	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,167 associations by consensus.

DYRK1A vs SCAF4 — BRCA

Explore this scatter interactively →