DYRK1A

Across TCGA patient cohorts, DYRK1A mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DYRK1A-associated genes across cancer lineages are Caspase-7-cleavedD198, ACC_pS79, and GATA6. Each is linked with DYRK1A in more than 2 cancer types. Because this analysis shows association rather than direction, both DYRK1A-to-partner and partner-to-DYRK1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by DYRK1A-low versus DYRK1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYRK1A→partner) and Y-score (partner→DYRK1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.432	+1.309	.006	.013	3	3
UCEC	ACC_pS79 →	+0.248	+0.906	.007	.041	3	2
UCEC	GATA6 →	-0.134	-1.874	.001	.002	3	2
UCEC	PCNA →	+0.170	+1.192	.003	.007	3	2
UCEC	PDCD4 →	-0.402	-1.338	.001	.005	3	2
UCEC	Rictor_pT1135 →	-0.058	-1.415	.033	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

Caspase-7-cleavedD198 by DYRK1A expression — UCEC

Explore this box plot interactively →