DYRK1A

Across TCGA cell cohorts, DYRK1A mutation is significantly associated with the RNA expression of many other genes, with 74 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DYRK1A-associated genes across cancer lineages are HTN3, FCN2, and STH. Each is linked with DYRK1A in more than 1 cancer types. Because this analysis shows association rather than direction, both DYRK1A-to-partner and partner-to-DYRK1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HTN3 grouped by DYRK1A-low versus DYRK1A-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYRK1A→partner) and Y-score (partner→DYRK1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	HTN3 →	+0.993	+4.169	<.001	.008	3	2
URINARY_TRACT	FCN2 →	+0.025	+4.087	<.001	.009	3	1
SKIN	STH →	+0.093	+4.196	<.001	.002	3	1
CNS	DBX1 →	+0.615	+4.315	<.001	.006	3	1
CNS	CDY2A →	+0.009	+4.321	<.001	.009	3	1
CNS	GK2 →	+0.009	+4.754	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 74 associations by consensus.

HTN3 by DYRK1A expression — CNS

Explore this box plot interactively →