DYNC2LI1

Across TCGA cell cohorts, DYNC2LI1 mutation is significantly associated with the mutation status of many other genes, with 1,749 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DYNC2LI1-associated genes across cancer lineages are KCNJ15, FBLN1, and LRP4. Each is linked with DYNC2LI1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DYNC2LI1-to-partner and partner-to-DYNC2LI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCNJ15 grouped by DYNC2LI1-low versus DYNC2LI1-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYNC2LI1→partner) and Y-score (partner→DYNC2LI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	KCNJ15 →	+4.807	+4.807	.008	.008	1	3
SKIN	FBLN1 →	+3.638	+4.117	.002	.002	1	3
SKIN	LRP4 →	+2.593	+4.282	.002	.002	1	3
LARGE_INTESTINE	AP1B1 →	+2.936	+4.471	.001	.001	1	3
LARGE_INTESTINE	PADI2 →	+3.744	+4.044	.003	.003	1	3
STOMACH	PTPN7 →	+4.807	+4.807	.008	.008	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,749 associations by consensus.

KCNJ15 by DYNC2LI1 expression — STOMACH

Explore this box plot interactively →