DYNC1LI2

Across TCGA cell cohorts, DYNC1LI2 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible DYNC1LI2-associated genes across cancer lineages are KLK12, KCNK18, and IFNA14. Each is linked with DYNC1LI2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DYNC1LI2-to-partner and partner-to-DYNC1LI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLK12 grouped by DYNC1LI2-low versus DYNC1LI2-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYNC1LI2→partner) and Y-score (partner→DYNC1LI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KLK12 →	+1.031	+4.930	<.001	.008	3	1
SOFT_TISSUE	KCNK18 →	+0.076	+5.977	<.001	.001	3	1
SOFT_TISSUE	IFNA14 →	+0.028	+5.369	<.001	.004	3	1
LARGE_INTESTINE	TMCO5A →	+0.019	+4.415	<.001	.007	3	1
LUNG_NSCLC_LUAD	OR10AG1 →	+0.043	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	PABPC1L2A →	+0.045	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

KLK12 by DYNC1LI2 expression — SOFT_TISSUE

Explore this box plot interactively →