Across TCGA patient cohorts, DXO mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DXO-associated genes across cancer lineages are XBP1, MEK1, and Myosin-IIa_pS1943. Each is linked with DXO in more than 1 cancer types. Because this analysis shows association rather than direction, both DXO-to-partner and partner-to-DXO results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DXO→partner) and Y-score (partner→DXO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	XBP1 →	-0.268	-2.986	<.001	.035	3	2
UCEC	MEK1 →	+0.448	+3.000	.019	.036	3	1
UCEC	Myosin-IIa_pS1943 →	+0.227	+2.183	.035	.035	3	1
UCEC	p27 →	+0.366	+3.169	.001	.019	3	1
UCEC	p62 Lck ligand →	+0.449	+3.179	.008	.010	3	1
UCEC	Tuberin_pT1462 →	+0.271	+2.179	.025	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

DXO survival (RNA) · tumor vs normal (RNA) · all DXO data types