Across TCGA pan-cancer cohorts, DXO RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of DXO’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where DXO RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DXO is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.
COAD, HNSC, and LIHC are the cancer types where DXO tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DXO RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.