DVL2

Across TCGA cell cohorts, DVL2 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DVL2-associated genes across cancer lineages are OR10R2, OR2D3, and POU3F4. Each is linked with DVL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DVL2-to-partner and partner-to-DVL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10R2 grouped by DVL2-low versus DVL2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DVL2→partner) and Y-score (partner→DVL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR10R2 →	+0.012	+4.887	.004	.009	3	2
UPPER_AERODIGESTIVE_TRACT	OR2D3 →	+0.045	+4.510	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	POU3F4 →	+0.036	+4.510	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	TRIM77 →	+0.022	+4.357	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	PAPOLB →	+0.137	+4.510	<.001	.003	3	1
LUNG_NSCLC_LUAD	F9 →	+0.006	+6.266	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

OR10R2 by DVL2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →