DVL1

Across TCGA patient cohorts, DVL1 protein abundance is significantly associated with the RNA expression of many other genes, with 10,129 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible DVL1-associated genes across cancer lineages are SCML2, CENPF, and TOPBP1. Each is linked with DVL1 in more than 3 cancer types. Because this analysis shows association rather than direction, both DVL1-to-partner and partner-to-DVL1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DVL1 versus SCML2 in HNSC, with a Pearson correlation of -0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DVL1→partner) and Y-score (partner→DVL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SCML2 →	-0.866	-0.456	<.001	<.001	3	4
BRCA	CENPF →	-1.112	-0.403	<.001	<.001	3	4
HNSC	TOPBP1 →	-0.646	-0.412	<.001	.003	3	4
HNSC	GPR19 →	-0.816	-0.481	<.001	<.001	3	4
HNSC	PARPBP →	-0.568	-0.321	.002	.007	3	4
BRCA	E2F2 →	-0.878	-0.423	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,129 associations by consensus.

DVL1 vs SCML2 — HNSC

Explore this scatter interactively →