DVL1

Across TCGA cell cohorts, DVL1 mutation is significantly associated with the RNA expression of many other genes, with 1,025 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DVL1-associated genes across cancer lineages are TRARG1, SCGB1C1, and OR6V1. Each is linked with DVL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DVL1-to-partner and partner-to-DVL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRARG1 grouped by DVL1-low versus DVL1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DVL1→partner) and Y-score (partner→DVL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TRARG1 →	+0.016	+4.142	<.001	.003	3	2
SOFT_TISSUE	SCGB1C1 →	+0.044	+4.392	<.001	.004	3	2
BLOOD_Lymphoma	OR6V1 →	+0.017	+3.584	<.001	.004	3	2
LARGE_INTESTINE	CASC3 →	+0.467	+3.321	.003	.003	3	2
LARGE_INTESTINE	UBE2D3 →	+0.460	+3.389	.002	.001	3	2
LARGE_INTESTINE	C12orf57 →	+0.804	+3.850	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,025 associations by consensus.

TRARG1 by DVL1 expression — SOFT_TISSUE

Explore this box plot interactively →