DUXA

Across TCGA patient cohorts, DUXA RNA expression is significantly associated with the go_rna of many other GO terms, with 6,489 significant associations in total. STAD shows the largest number of these associations.

The most reproducible DUXA-associated GO terms across cancer lineages are RNA destabilization, Positive regulation of mRNA metabolic process, and Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. Each is linked with DUXA in more than 11 cancer types. Because this analysis shows association rather than direction, both DUXA-to-partner and partner-to-DUXA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA destabilization grouped by DUXA-low versus DUXA-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DUXA→partner) and Y-score (partner→DUXA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	RNA destabilization →	+0.057	+0.183	<.001	<.001	3	12
STAD	Positive regulation of mRNA metabolic process →	+0.065	+0.157	<.001	<.001	3	11
STAD	Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay →	+0.076	+0.170	<.001	<.001	3	11
STAD	Respiratory system development →	+0.053	+0.148	<.001	<.001	3	11
STAD	Myeloid cell homeostasis →	+0.067	+0.149	<.001	<.001	3	10
STAD	Negative regulation of MAPK cascade →	+0.058	+0.163	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,489 associations by consensus.

RNA destabilization by DUXA expression — STAD

Explore this box plot interactively →