DUXA

Across TCGA pan-cancer cohorts, DUXA RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated DUXA data layer compared with 2 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher DUXA RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DUXA expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

ACC, STAD, and LUSC are the cancer types where DUXA RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	All	0.185	0.821	<.001	63	view →
STAD	OS	Tertile	III,IV	0.275	0.585	.003	44	view →
LUSC	OS	Quartile	All	0.711	0.844	.014	39	view →
CESC	OS	Tertile	IV	0.091	0.593	<.001	36	view →
THYM	DFS	Tertile	All	0.616	0.883	.006	33	view →
BRCA	OS	Tertile	All	0.405	0.608	<.001	33	view →
LIHC	DFS	Tertile	All	0.245	0.457	.009	30	view →
READ	DFS	Tertile	IV	0.027	0.636	<.001	27	view →
SKCM	OS	Tertile	IV	0.415	0.861	.014	24	view →
MESO	DFS	Quartile	All	0.099	0.479	.005	12	view →
TGCT	DFS	Median	II,III,IV	0.757	1.000	.030	10	view →
BLCA	OS	Tertile	IV	0.156	0.587	.022	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

DUXA–ACC (OS)

Open the ACC breakdown →