DUXA

Across TCGA patient cohorts, DUXA mutation is significantly associated with the RNA expression of many other genes, with 3,071 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DUXA-associated genes across cancer lineages are SNRPD3, RTCB, and PPP6R2. Each is linked with DUXA in more than 1 cancer types. Because this analysis shows association rather than direction, both DUXA-to-partner and partner-to-DUXA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNRPD3 grouped by DUXA-low versus DUXA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DUXA→partner) and Y-score (partner→DUXA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNRPD3 →	+0.336	+1.847	.004	.009	3	2
UCEC	RTCB →	+0.609	+2.790	<.001	<.001	3	2
SKCM	PPP6R2 →	+0.394	+3.397	.003	.004	3	2
UCEC	RHBDD3 →	+0.475	+2.736	.001	<.001	3	2
SKCM	MCM5 →	+0.719	+2.925	<.001	.001	3	2
SKCM	FAM118A →	+0.649	+3.700	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,071 associations by consensus.

SNRPD3 by DUXA expression — UCEC

Explore this box plot interactively →