DUXA

Across TCGA patient cohorts, DUXA mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DUXA-associated genes across cancer lineages are FoxM1, Caspase-7-cleavedD198, and Cyclin-B1. Each is linked with DUXA in more than 1 cancer types. Because this analysis shows association rather than direction, both DUXA-to-partner and partner-to-DUXA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by DUXA-low versus DUXA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DUXA→partner) and Y-score (partner→DUXA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.223	+1.584	.028	.036	3	2
UCEC	Caspase-7-cleavedD198 →	+0.644	+2.019	.005	.017	3	2
UCEC	Cyclin-B1 →	+0.735	+3.584	<.001	.002	3	2
UCEC	Di-Ras3 →	-0.133	-2.986	.022	.035	3	2
UCEC	14-3-3_beta →	-0.096	-1.571	.015	.036	3	1
UCEC	EGFR_pY1068 →	-0.233	-3.584	.017	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

FoxM1 by DUXA expression — UCEC

Explore this box plot interactively →