DUXA

Across TCGA cell cohorts, DUXA mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible DUXA-associated genes across cancer lineages are CCL18, PRAMEF1, and ADGRG4. Each is linked with DUXA in more than 1 cancer types. Because this analysis shows association rather than direction, both DUXA-to-partner and partner-to-DUXA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCL18 grouped by DUXA-low versus DUXA-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DUXA→partner) and Y-score (partner→DUXA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CCL18 →	+0.097	+4.415	<.001	.007	3	1
BLOOD_Leukemia	PRAMEF1 →	+0.012	+5.569	<.001	.001	3	1
BLOOD_Leukemia	ADGRG4 →	+0.004	+4.539	<.001	.007	3	1
SKIN	KLHL1 →	+0.016	+4.054	<.001	.004	3	1
SKIN	PPIAL4E →	+0.048	+4.347	<.001	.001	3	1
SKIN	WNT8A →	+0.016	+3.930	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

CCL18 by DUXA expression — LARGE_INTESTINE

Explore this box plot interactively →