DUX4L47

Across TCGA pan-cancer cohorts, DUX4L47 RNA is linked to patient survival in 8 of 34 cancer types, making it the most broadly survival-associated DUX4L47 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DUX4L47 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated DUX4L47 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, THYM, and KIRP are the cancer types where DUX4L47 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	II,III,IV	0.825	0.671	.027	63	view →
THYM	DFS	Tertile	II,III,IV	0.145	0.873	<.001	24	view →
KIRP	OS	Tertile	All	0.210	0.715	.005	24	view →
OV	DFS	Tertile	IV	0.125	0.476	.001	18	view →
UCEC	DFS	Tertile	All	0.405	0.681	.021	12	view →
GBM	DFS	Tertile	All	0.095	0.299	.031	9	view →
SKCM	DFS	Tertile	All	0.844	0.610	.018	9	view →
STAD	OS	Tertile	IV	0.645	0.289	.048	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

DUX4L47–HNSC (DFS)

Open the HNSC breakdown →