DUX4L46

Across TCGA patient cohorts, DUX4L46 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,376 significant associations in total. STAD shows the largest number of these associations.

The most reproducible DUX4L46-associated GO terms across cancer lineages are tRNA metabolic process, rRNA metabolic process, and Regulation of DNA-templated transcription initiation. Each is linked with DUX4L46 in more than 13 cancer types. Because this analysis shows association rather than direction, both DUX4L46-to-partner and partner-to-DUX4L46 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, tRNA metabolic process grouped by DUX4L46-low versus DUX4L46-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DUX4L46→partner) and Y-score (partner→DUX4L46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	tRNA metabolic process →	+0.047	+0.153	<.001	<.001	3	14
UCEC	rRNA metabolic process →	+0.046	+0.022	<.001	<.001	3	13
UCEC	Regulation of DNA-templated transcription initiation →	+0.036	+0.030	<.001	.001	3	13
STAD	Transcription initiation at RNA polymerase II promoter →	+0.068	+0.198	<.001	<.001	3	13
UCEC	Protein acetylation →	+0.038	+0.037	<.001	<.001	3	13
UCEC	Protein targeting to mitochondrion →	+0.043	+0.021	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,376 associations by consensus.

tRNA metabolic process by DUX4L46 expression — STAD

Explore this box plot interactively →