DUX4L46

Across TCGA pan-cancer cohorts, DUX4L46 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of DUX4L46’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where DUX4L46 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DUX4L46 is over-expressed in tumor, although a few such as ESCA show the opposite, repressed pattern.

KIRC, KIRP, and ESCA are the cancer types where DUX4L46 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DUX4L46 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	III,IV	+0.037	.015	4	view →
KIRP	Female	All	+0.046	.012	2	view →
ESCA	All	All	−0.102	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

DUX4L46–KIRC

Open the KIRC breakdown →