double homeobox 4 like 27 (pseudogene)Genealiases: []
Q-omics provides the consensus-scored DUX4L27 profile across patient tissues and cancer cell-line models. DUX4L27 expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in BRCA. Among the 18 cancer types available for tumor–normal comparison, DUX4L27 is differentially expressed in 9, with the highest sampling consensus in COAD. Additionally, DUX4L27 RNA expression shows 13,887 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight BRCA, COAD, and THYM as cancer lineages where DUX4L27 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for DUX4L27 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes DUX4L27 survival associations across molecular data types. DUX4L27 RNA expression shows survival associations in the most cancer types (22). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible DUX4L27 RNA expression–survival associations across cancer types. High DUX4L27 expression shows unfavorable associations in LUSC, but favorable associations in BRCA, KIRC, THYM, THCA and SARC. The BRCA Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify BRCA as the clearest survival context for DUX4L27 RNA expression.
This table summarizes DUX4L27 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 9. The strongest signals are observed in COAD for RNA.
This table ranks reproducible tumor–normal expression differences for DUX4L27. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. DUX4L27 shows lower tumor expression in COAD, KIRC, KICH, KIRP and BRCA and higher tumor expression in LIHC. The COAD box plot shows higher DUX4L27 RNA expression in normal versus tumor tissue (log2 FC = −0.186, t-test p < 0.001).
This table shows molecular features associated with DUX4L27 in patient tissues and cancer cell lines. In patient samples, DUX4L27 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set.
