DUX4L19

Across TCGA pan-cancer cohorts, DUX4L19 RNA is linked to patient survival in 6 of 34 cancer types, making it the most broadly survival-associated DUX4L19 data layer.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher DUX4L19 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DUX4L19 expression acts as an unfavorable survival marker.

UCEC, KICH, and THYM are the cancer types where DUX4L19 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	II,III,IV	0.168	0.742	<.001	72	view →
KICH	OS	Tertile	All	0.439	0.893	<.001	69	view →
THYM	OS	Tertile	All	0.582	0.980	<.001	39	view →
PAAD	DFS	Tertile	All	0.198	0.470	.021	18	view →
LAML	DFS	Tertile	All	0.203	0.628	<.001	18	view →
GBM	DFS	Tertile	All	0.048	0.242	.006	9	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

DUX4L19–UCEC (DFS)

Open the UCEC breakdown →