Across TCGA patient cohorts, DUX4 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,502 significant associations in total. STAD shows the largest number of these associations.

The most reproducible DUX4-associated GO terms across cancer lineages are Establishment of protein localization to mitochondrial membrane, Peptidyl-arginine modification, and Viral budding. Each is linked with DUX4 in more than 6 cancer types. Because this analysis shows association rather than direction, both DUX4-to-partner and partner-to-DUX4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DUX4→partner) and Y-score (partner→DUX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Establishment of protein localization to mitochondrial membrane →	+0.088	+0.015	<.001	<.001	3	7
STAD	Peptidyl-arginine modification →	+0.045	+0.013	<.001	<.001	3	7
STAD	Viral budding →	+0.072	+0.012	<.001	<.001	3	6
STAD	Protein monoubiquitination →	+0.078	+0.015	<.001	<.001	3	6
STAD	ATP metabolic process →	+0.095	+0.014	<.001	<.001	3	6
STAD	Nucleoside phosphate biosynthetic process →	+0.077	+0.013	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,502 associations by consensus.

Exploration

DUX4 survival (RNA) · tumor vs normal (RNA) · all DUX4 data types