DUX4

Across TCGA pan-cancer cohorts, DUX4 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of DUX4’s most consistent transcriptional readouts.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where DUX4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DUX4 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

UCEC, KIRP, and THCA are the cancer types where DUX4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DUX4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
UCEC	All	All	+0.039	.043	2	view →
KIRP	All	III,IV	+0.009	.038	1	view →
THCA	All	All	−0.003	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

DUX4–UCEC

Open the UCEC breakdown →