DUX4

Across TCGA cell cohorts, DUX4 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,038 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DUX4-associated GO terms across cancer lineages are SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, Regulation of myoblast fusion, and Base-excision repair, gap-filling. Each is linked with DUX4 in more than 7 cancer types. Because this analysis shows association rather than direction, both DUX4-to-partner and partner-to-DUX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process grouped by DUX4-low versus DUX4-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DUX4→partner) and Y-score (partner→DUX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process →	+0.059	+0.055	<.001	<.001	3	7
BLOOD_Lymphoma	Regulation of myoblast fusion →	+0.065	+0.028	.002	.007	2	8
LARGE_INTESTINE	Base-excision repair, gap-filling →	+0.100	+0.034	<.001	.002	3	7
UPPER_AERODIGESTIVE_TRACT	Regulation of protein localization to endoplasmic reticulum →	+0.095	+0.017	.001	.004	3	6
OVARY	Positive regulation of protein localization to endoplasmic reticulum →	+0.099	+0.036	<.001	.008	3	6
UPPER_AERODIGESTIVE_TRACT	Cilium movement involved in cell motility →	-0.104	-0.016	<.001	.007	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,038 associations by consensus.

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process by DUX4 expression — OESOPHAGUS

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