DUT

Across TCGA patient cohorts, DUT mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DUT-associated genes across cancer lineages are c-Met_pY1235, Notch1, and Rictor_pT1135. Each is linked with DUT in more than 1 cancer types. Because this analysis shows association rather than direction, both DUT-to-partner and partner-to-DUT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by DUT-low versus DUT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DUT→partner) and Y-score (partner→DUT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.079	+3.179	.033	.010	3	2
UCEC	Notch1 →	+0.204	+2.321	.003	.035	3	1
UCEC	Rictor_pT1135 →	-0.104	-2.321	.042	.035	3	1
UCEC	Tuberin →	+0.444	+3.009	.001	.019	3	1
UCEC	BRCA2 →	-0.133	-3.314	.045	.010	3	1
UCEC	eIF4E →	+0.266	+3.459	.011	.005	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

c-Met_pY1235 by DUT expression — UCEC

Explore this box plot interactively →