Across TCGA cell cohorts, DUSP8 mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. LUNG_NSCLC_LUSC shows the largest number of these associations.

The most reproducible DUSP8-associated genes across cancer lineages are OR6C70, NOBOX, and PF4V1. Each is linked with DUSP8 in more than 1 cancer types. Because this analysis shows association rather than direction, both DUSP8-to-partner and partner-to-DUSP8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DUSP8→partner) and Y-score (partner→DUSP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR6C70 →	+0.486	+6.266	<.001	<.001	3	2
LUNG_NSCLC_LUSC	NOBOX →	+0.040	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	PF4V1 →	+0.296	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	LCN9 →	+0.036	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	PRG3 →	+0.023	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	C10orf71 →	+0.013	+4.643	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Exploration

DUSP8 survival (RNA) · tumor vs normal (RNA) · all DUSP8 data types