DUSP6

Across TCGA patient cohorts, DUSP6 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DUSP6-associated genes across cancer lineages are FoxM1, EGFR_pY1068, and JNK_pT183_Y185. Each is linked with DUSP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both DUSP6-to-partner and partner-to-DUSP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by DUSP6-low versus DUSP6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DUSP6→partner) and Y-score (partner→DUSP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.358	+2.321	.005	.035	3	2
UCEC	EGFR_pY1068 →	-0.332	-2.321	.008	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.207	-2.308	.014	.036	3	1
UCEC	JNK2 →	+0.287	+2.834	.004	.034	3	1
UCEC	p62 Lck ligand →	+0.460	+3.179	.004	.010	3	1
UCEC	PKC-delta_pS664 →	-0.167	-3.459	.005	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

FoxM1 by DUSP6 expression — UCEC

Explore this box plot interactively →