DUSP6

Across TCGA cell cohorts, DUSP6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,557 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible DUSP6-associated GO terms across cancer lineages are Negative regulation of lens fiber cell differentiation, Peptidyl-tyrosine dephosphorylation, and Regulation of lens fiber cell differentiation. Each is linked with DUSP6 in more than 13 cancer types. Because this analysis shows association rather than direction, both DUSP6-to-partner and partner-to-DUSP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of lens fiber cell differentiation grouped by DUSP6-low versus DUSP6-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DUSP6→partner) and Y-score (partner→DUSP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of lens fiber cell differentiation →	+1.271	+2.148	<.001	<.001	3	13
URINARY_TRACT	Peptidyl-tyrosine dephosphorylation →	+0.125	+2.374	<.001	.001	2	14
BLOOD_Myeloma	Regulation of lens fiber cell differentiation →	+1.215	+3.010	.004	.002	3	11
PANCREAS	Negative regulation of MAPK cascade →	+0.051	+1.599	.002	.001	3	10
BREAST	Peptidyl-threonine dephosphorylation →	+0.087	+1.392	<.001	.009	3	10
PANCREAS	Negative regulation of ERK1 and ERK2 cascade →	+0.091	+1.832	<.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,557 associations by consensus.

Negative regulation of lens fiber cell differentiation by DUSP6 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →