DUSP6

Across TCGA cell cohorts, DUSP6 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible DUSP6-associated genes across cancer lineages are FGF6, OR4D11, and OR2L8. Each is linked with DUSP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both DUSP6-to-partner and partner-to-DUSP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FGF6 grouped by DUSP6-low versus DUSP6-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DUSP6→partner) and Y-score (partner→DUSP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	FGF6 →	+0.225	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR4D11 →	+0.023	+6.266	<.001	<.001	3	1
LUNG_NSCLC_LUAD	OR2L8 →	+0.020	+6.266	<.001	<.001	3	1
LUNG_NSCLC_LUAD	MLN →	+0.087	+5.228	<.001	.005	3	1
LARGE_INTESTINE	VSIG4 →	+0.021	+4.054	.008	.004	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

FGF6 by DUSP6 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →